abstract：:Thrombocytopenia is a characteristic feature during the acute phase of dengue infection and has been found to associate with vascular leakage in severe dengue. Although dengue antigens have been observed in platelets, there is no strong evidence to suggest a direct infection of platelets by dengue virus as a contribut...

journal_title：Open forum infectious diseases

authors： Kar M,Singla M,Chandele A,Kabra SK,Lodha R,Medigeshi GR

更新日期：2017-03-23 00:00:00

abstract：BACKGROUND:Invasive group A Streptococcus (iGAS) disease caused by type emm89 strains has been increasing worldwide, driven by the emergence of an epidemic clonal variant (clade 3 emm89). The clinical characteristics of patients with emm89 iGAS disease, and in particular with clade 3 emm89 iGAS disease, are poorly desc...

journal_title：Open forum infectious diseases

authors： Teatero S,Coleman BL,Beres SB,Olsen RJ,Kandel C,Reynolds O,Athey TBT,Musser JM,McGeer A,Fittipaldi N

更新日期：2017-03-04 00:00:00

abstract：BACKGROUND:Infection causes 1 of every 5 neonatal deaths globally. Group B Streptococcus (GBS) is the most significant pathogen, although little is known about its epidemiology and risk in low-income countries. METHODS:A cross-sectional study in 2015 at a public hospital in Guatemala City enrolled women ≥35 weeks' ges...

journal_title：Open forum infectious diseases

authors： Rick AM,Aguilar A,Cortes R,Gordillo R,Melgar M,Samayoa-Reyes G,Frank DN,Asturias EJ

更新日期：2017-02-08 00:00:00

abstract：BACKGROUND:The incidence of recurrent herpes zoster (HZ) and the relationship between initial and recurrent HZ are not clear. METHODS:The Miyazaki Dermatologist Society has surveyed ~5000 patients with HZ annually since 1997. A questionnaire regarding HZ and its recurrence was completed by the dermatologists. RESULTS...

journal_title：Open forum infectious diseases

authors： Shiraki K,Toyama N,Daikoku T,Yajima M,Miyazaki Dermatologist Society.

更新日期：2017-01-28 00:00:00

abstract：BACKGROUND:Antiretroviral therapy (ART) is recommended for all people living with human immunodeficiency virus (HIV), yet physician attitudes and prescribing behaviors toward members of key risk populations may limit ART access and undermine treatment as prevention strategies. METHODS:Physicians in Malaysia (N = 214) ...

journal_title：Open forum infectious diseases

authors： Ferro EG,Culbert GJ,Wickersham JA,Marcus R,Steffen AD,Pauls HA,Westergaard RP,Lee CK,Kamarulzaman A,Altice FL

更新日期：2017-01-25 00:00:00

abstract：BACKGROUND:Immune activation persists despite suppressive antiretroviral therapy (ART) in human immunodeficiency virus (HIV) infection and predicts non-Acquired Immune Deficiency Syndrome (AIDS) comorbidities including cardiovascular disease. Activated platelets play a key role in atherothrombosis and inflammation, and...

journal_title：Open forum infectious diseases

authors： O'Brien MP,Hunt PW,Kitch DW,Klingman K,Stein JH,Funderburg NT,Berger JS,Tebas P,Clagett B,Moisi D,Utay NS,Aweeka F,Aberg JA

更新日期：2017-01-19 00:00:00

abstract：BACKGROUND:Invasive aspergillosis (IA) and mucormycosis contribute to substantial mortality, especially among immunocompromised persons, including those with hematopoietic stem cell transplant (HSCT), hematologic malignancy (HM), and solid organ transplant (SOT). METHODS:Using International Classification of Diseases,...

journal_title：Open forum infectious diseases

authors： Vallabhaneni S,Benedict K,Derado G,Mody RK

更新日期：2017-01-13 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus (HIV)-associated neurocognitive disorders occurs in 20%-50% of HIV-positive patients. We undertook this study to assess the prevalence of a positive screen for cognitive impairment in the clinic population at our institution and to demonstrate the feasibility of implementing a sc...

journal_title：Open forum infectious diseases

authors： McNamara PH,Coen R,Redmond J,Doherty CP,Bergin C

更新日期：2016-12-27 00:00:00

abstract：BACKGROUND:Intra-abdominal infections (IAI) constitute a common reason for hospitalization. However, there is lack of standardization in empiric management of (1) anaerobes, (2) enterococci, (3) fungi, and (4) multidrug-resistant organisms (MDRO). The recommendation is to institute empiric coverage for some of these or...

journal_title：Open forum infectious diseases

authors： Marcus G,Levy S,Salhab G,Mengesha B,Tzuman O,Shur S,Burke E,Mayeda RC,Cochavi L,Perluk I,Zaidenstein R,Lazarovitch T,Dadon M,Marchaim D

更新日期：2016-12-20 00:00:00

abstract：:This report describes a case of relapsing pneumococcal peritonitis. The postulated source of infection was vaginal colonization and secondary adherence of pneumococci to an intrauterine contraceptive device. After immunization with a conjugate pneumococcal vaccine, her antibody levels were observed. She remained infec...

journal_title：Open forum infectious diseases

authors： Sendi P,Moser Schaub EM,Nirgianakis K,Hathaway LJ,Bittel P,Goldblatt D,Streit S

更新日期：2016-12-07 00:00:00

abstract：:The FilmArray meningitis/encephalitis (ME) panel is a novel syndromic, nucleic acid amplification test for diagnosis of acute meningitis and encephalitis. Emerging data on its performance are concerning for false-positive results. We present a case of tuberculous meningitis misdiagnosed as herpes simplex virus-1 encep...

journal_title：Open forum infectious diseases

authors： Gomez CA,Pinsky BA,Liu A,Banaei N

更新日期：2016-12-07 00:00:00

abstract：: Background.  Successful treatment of infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa is thwarted by the emergence of antibiotic resistance and biofilm formation on prosthetic devices. Our aims were to decipher the molecular basis of resistance in a un...

journal_title：Open forum infectious diseases

authors： Domitrovic TN,Hujer AM,Perez F,Marshall SH,Hujer KM,Woc-Colburn LE,Parta M,Bonomo RA

更新日期：2016-10-21 00:00:00

abstract：: Background.  Herpes zoster, or shingles, is a common, painful reactivation of latent varicella zoster virus infection. Understanding host factors that predispose to herpes zoster may permit development of more effective prevention strategies. Our objective was to examine m...

journal_title：Open forum infectious diseases

authors： Levinson RT,Hulgan T,Kalams SA,Fessel JP,Samuels DC

更新日期：2016-10-19 00:00:00

abstract：:Fusarium species are ubiquitous fungi causing a wide array of infections, including invasive disease in the immunosuppressed. We present a fusarium bone infection in a child with Pearson syndrome and review the literature. Ten cases of fusarium osteomyelitis were reported in the past 40 years, and we review the treatm...

journal_title：Open forum infectious diseases

authors： Hiebert RM,Welliver RC,Yu Z

更新日期：2016-10-07 00:00:00

abstract：BACKGROUND:Our objective was to study the prognostic value of liver stiffness (LS) in HIV-infected patients with chronic hepatitis C (CHC). METHODS:We analyzed HIV-infected patients with compensated CHC and at least 1 determination of LS. The primary outcome was the occurrence of liver-related events (LRE), namely, de...

journal_title：Open forum infectious diseases

authors： Pérez-Latorre L,Rivero-Juárez A,Hontañón V,Díez C,Cuenca F,Martín-Carbonero ML,Montes ML,Bellón JM,Aldámiz-Echevarría T,Carrero A,Rivero A,González-García J,Berenguer J

更新日期：2016-10-03 00:00:00

abstract：:Because of concerns about possible emergence of artemisinin resistance strains of Plasmodium falciparum in mining areas of the interior of Guyana, a 7-day artesunate trial was conducted from March to December 2014. The day-3 parasite clearance rate, the efficacy of artesunate at day 28, and polymorphism of Kelch 13 (P...

journal_title：Open forum infectious diseases

authors： Rahman R,Martin MJ,Persaud S,Ceron N,Kellman D,Musset L,Carter KH,Ringwald P

更新日期：2016-08-30 00:00:00

abstract：: Background.  The mechanism of virologic failure (VF) of lopinavir/ritonavir (LPV/r) monotherapy is not well understood. We assessed sequence changes in human immunodeficiency virus-1 reverse-transcriptase (RT) and protease (PR) regions. Methods. ...

journal_title：Open forum infectious diseases

authors： Vardhanabhuti S,Katzenstein D,Bartlett J,Kumarasamy N,Wallis CL

更新日期：2016-08-24 00:00:00

abstract：:It is a striking observation that tissue of patients invaded by the deep mycoses often lacks evidence of an inflammatory response. This lack of host response is often attributed to neutropenia secondary to chemotherapy. However, systematic studies do not support this simplistic explanation. However, invasive fungal le...

journal_title：Open forum infectious diseases

authors： Klotz SA,Sobonya RE,Lipke PN,Garcia-Sherman MC

更新日期：2016-08-03 00:00:00

abstract：:People living with human immunodeficiency virus frequently use dietary supplements, including probiotics, but concern exists about ingesting live organisms. We performed a systematic review of the benefits of probiotics and a meta-analysis of sepsis risk. We undertook a protocol-driven, comprehensive review to identif...

journal_title：Open forum infectious diseases

authors： Carter GM,Esmaeili A,Shah H,Indyk D,Johnson M,Andreae M,Sacks HS

更新日期：2016-07-29 00:00:00

abstract：: Background.  Many human immunodeficiency virus (HIV)-infected patients remain on nevirapine-based antiretroviral therapy (ART) despite safety and efficacy concerns. Switching to a rilpivirine-based regimen is an alternative, but there is little experience with rilpivirine ...

journal_title：Open forum infectious diseases

authors： Collins SE,Grant PM,Uwinkindi F,Talbot A,Seruyange E,Slamowitz D,Mugeni A,Remera E,Niyonsenga SP,Nyirimigabo J,Uwizihiwe JP,Dongier P,Muhayimpundu R,Mazarati JB,Zolopa A,Nsanzimana S

更新日期：2016-07-01 00:00:00

abstract：:Background.  Hepatitis C virus (HCV) treatment access among human immunodeficiency virus (HIV)/HCV-coinfected people who inject drugs is poor, despite a high burden of disease in this population. Understanding barriers and facilitators to HCV treatment uptake is critical to the implementation of new direct-acting anti...

journal_title：Open forum infectious diseases

authors： Chu CE,Wu F,He X,Zhou K,Cheng Y,Cai W,Geng E,Volberding P,Tucker JD

更新日期：2016-06-24 00:00:00

abstract：:Elimination of a rifamycin from the treatment regimen for tuberculosis negatively impacts outcomes. Cross-reactivity between the rifamycins after drug eruptions is unclear. We report 6 consecutive human immunodeficiency virus-infected patients with rifampicin-associated drug rash with eosinophilia and systemic symptom...

journal_title：Open forum infectious diseases

authors： Lehloenya RJ,Dlamini S,Muloiwa R,Kakande B,Ngwanya MR,Todd G,Dheda K

更新日期：2016-06-20 00:00:00

abstract：:Methods.  In a cross-sectional substudy of the Multicenter AIDS Cohort Study, noncontrast cardiac computed tomography (CT) scanning for coronary artery calcium (CAC) scoring was performed on all men, and, for men with normal renal function, coronary CT angiography (CTA) was performed. Associations between fat depots (...

journal_title：Open forum infectious diseases

authors： Palella FJ Jr,McKibben R,Post WS,Li X,Budoff M,Kingsley L,Witt MD,Jacobson LP,Brown TT

更新日期：2016-06-16 00:00:00

abstract：:Background.  The causes of varicella-zoster virus reactivation and herpes zoster (HZ) are largely unknown. We assessed potential risk factors for HZ, the data for which cannot be obtained from the medical sector. Methods.  We conducted a matched case-control study. We established active surveillance in Olmsted County,...

journal_title：Open forum infectious diseases

authors： Marin M,Harpaz R,Zhang J,Wollan PC,Bialek SR,Yawn BP

更新日期：2016-06-11 00:00:00

abstract：:We used ribonucleic acid sequencing to profile Candida albicans transcription within biliary fluid from a patient with cholangitis; samples were collected before and after treatment with fluconazole and drainage. Candida albicans transcriptomes at the infection site distinguished treated from untreated cholangitis. Af...

journal_title：Open forum infectious diseases

authors： Clancy CJ,Meslin C,Badrane H,Cheng S,Losada LC,Nierman WC,Vergidis P,Clark NL,Nguyen MH

更新日期：2016-06-11 00:00:00

abstract：: Background.  School closures are an important mitigation strategy during influenza pandemic: if implemented early in a local outbreak, they can slow the disease spread in the surrounding community. During seasonal influenza epidemics, school closures may occur reactively, ...

journal_title：Open forum infectious diseases

authors： Russell ES,Zheteyeva Y,Gao H,Shi J,Rainey JJ,Thoroughman D,Uzicanin A

更新日期：2016-05-25 00:00:00

abstract：:Background.  The efficacy of live, attenuated live attenuated influenza vaccine(LAIV) and inactivated influenza vaccine(IIV) is poorly explained by either single or composite immune responses to vaccination. Protective biomarkers were therefore studied in response to LAIV or IIV followed by LAIV challenge in children....

journal_title：Open forum infectious diseases

authors： Wright PF,Hoen AG,Ilyushina NA,Brown EP,Ackerman ME,Wieland-Alter W,Connor RI,Jegaskanda S,Rosenberg-Hasson Y,Haynes BC,Luke CJ,Subbarao K,Treanor JJ

更新日期：2016-05-23 00:00:00

abstract：:Background.  During pregnancy, the placenta is inaccessible for diagnosis of placental malaria (PM), but soluble tumor necrosis factor-α receptors (sTNFR) are elevated in the plasma of women with PM. Methods.  In this study, sTNFR-1 and sTNFR-2 were quantified in urine of pregnant and nonpregnant Cameroonian women who...

journal_title：Open forum infectious diseases

authors： Tassi Yunga S,Thévenon AD,Leke RG,Taylor DW

更新日期：2016-04-26 00:00:00

abstract：:Toxoplasma encephalitis is a well recognized complication of acquired immune deficiency syndrome, solid organ transplantation, and allogeneic hematopoietic stem cell transplantation (HSCT). However, patients with hematologic malignancies not treated with allogeneic HSCT may also develop this condition, which requires ...

journal_title：Open forum infectious diseases

authors： Morjaria S,Epstein DJ,Romero FA,Taur Y,Seo SK,Papanicolaou GA,Hatzoglou V,Rosenblum M,Perales MA,Scordo M,Kaltsas A

更新日期：2016-03-30 00:00:00

abstract：:During 12 recent months of periodic influenza virus surveillance at 9 live poultry markets in Wuxi City China, we identified multiple highly pathogenic H5N6, H5N8, H5N2, and H5N1 avian influenza viruses. The variety of potentially pandemic viruses in this low-risk area is disconcerting and portends an increased pandem...

journal_title：Open forum infectious diseases

authors： Ma MJ,Chen SH,Wang GL,Zhao T,Qian YH,Wu MN,Liu Y,Gray GC,Lu B,Cao WC

更新日期：2016-03-09 00:00:00

abstract：:Background.  Advanced fibrosis occurs more commonly in human immunodeficiency virus (HIV)-hepatitis B virus (HBV) coinfected individuals; therefore, fibrosis monitoring is important in this population. However, transient elastography (TE) data in HIV-HBV coinfection are lacking. We aimed to assess liver fibrosis using...

journal_title：Open forum infectious diseases

authors： Audsley J,Robson C,Aitchison S,Matthews GV,Iser D,Sasadeusz J,Lewin SR

更新日期：2016-02-12 00:00:00

abstract：:Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus...

journal_title：Open forum infectious diseases

authors： Page K,Mirzazadeh A,Rice TM,Grebely J,Kim AY,Cox AL,Morris MD,Hellard M,Bruneau J,Shoukry NH,Dore GJ,Maher L,Lloyd AR,Lauer G,Prins M,McGovern BH

更新日期：2016-02-08 00:00:00

abstract：:Background.  Sepsis is a major cause of morbidity and mortality among older adults. The main goals of this study were to assess the association of sepsis at intensive care unit (ICU) admission with mortality and to identify predictors associated with increased mortality in older adults. Methods.  We conducted a prospe...

journal_title：Open forum infectious diseases

authors： Rowe T,Araujo KL,Van Ness PH,Pisani MA,Juthani-Mehta M

更新日期：2016-01-21 00:00:00

abstract：:Background.  Autochthonous hepatitis E virus (HEV) infection has been reported in over 200 solid organ transplant (SOT) recipients since 2006, yet little is known about the burden of HEV among SOT recipients in North America. We performed a retrospective, cross-sectional study to investigate the prevalence and risk fa...

journal_title：Open forum infectious diseases

authors： Sue PK,Pisanic N,Heaney CD,Forman M,Valsamakis A,Jackson AM,Ticehurst JR,Montgomery RA,Schwarz KB,Nelson KE,Karnsakul W

更新日期：2016-01-18 00:00:00

abstract：:In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretroviral therapy optimiz...

journal_title：Open forum infectious diseases

authors： Béguelin C,Vázquez M,Bertschi M,Yerly S,de Jong D,Gutbrod K,Rauch A,Cusini A

更新日期：2015-12-28 00:00:00

abstract：:Far East scarlet-like fever (FESLF) is a severe inflammatory disease that occurs sporadically and in outbreaks in Russia and Japan. Far East scarlet-like fever is caused by Yersinia pseudotubuclosis infection, an organism that typically causes self-limiting gastroenteritis in Europe. Studies suggest the ability of Far...

journal_title：Open forum infectious diseases

authors： Amphlett A

更新日期：2015-12-17 00:00:00

abstract：:Background.  Sepsis is a serious and common condition with high mortality and morbidity. The public awareness, knowledge, and perception of sepsis in Sweden are unknown. Methods.  A survey was performed using an online interview distributed to adults, aged 18-74, between March 6 and 9, 2015. Results.  A total of 1001 ...

journal_title：Open forum infectious diseases

authors： Mellhammar L,Christensson B,Linder A

更新日期：2015-10-26 00:00:00

abstract：:Background.  Varicella is a highly contagious vaccine-preventable illness. In 1996, the Advisory Committee for Immunization Practices recommended 1 dose of vaccine for children, and in 2006 it recommended 2 doses; Connecticut required 1 dose for school entry in 2000 and 2 doses for school entry starting in 2011. Conne...

journal_title：Open forum infectious diseases

authors： Mullins J,Kudish K,Sosa L,Hadler J

更新日期：2015-10-09 00:00:00

abstract：:Background.  The majority of Lyme disease cases in the United States are acquired on the east coast between northern Virginia and New England. In recent years the geographic extent of Lyme disease has been expanding, raising the prospect of Lyme disease becoming endemic in the southeast. Methods.  We collected confirm...

journal_title：Open forum infectious diseases

authors： Lantos PM,Nigrovic LE,Auwaerter PG,Fowler VG Jr,Ruffin F,Brinkerhoff RJ,Reber J,Williams C,Broyhill J,Pan WK,Gaines DN

更新日期：2015-09-27 00:00:00

abstract：:The spectrum of West Nile virus (WNV) infection continues to be elucidated. Many cases of WNV are asymptomatic; however, in immunocompromised patients, symptoms are more likely to be severe. We describe fatal WNV central nervous system disease in lymphoma patients who received rituximab, blunting the inflammatory resp...

journal_title：Open forum infectious diseases

authors： Morjaria S,Arguello E,Taur Y,Sepkowitz K,Hatzoglou V,Nemade A,Rosenblum M,Cavalcanti MS,Palomba ML,Kaltsas A

更新日期：2015-09-19 00:00:00